Similarly, in mild cognitive impairment (MCI) subjects and early Alzheimer’s disease (AD) state, the expression of glycolytic factors increased, and HIF-1 mediated brain autoregulation may have early adaptation to oxidative and inflammatory stress in enhancing cerebral blood flow and antioxidant pathways, so as to reduce neuronal death [50]. The gene discussed is SETD2; the disease is early-onset autosomal dominant Alzheimer disease.