Statistically significant differences were found in IgE levels (216 [288] vs 43.5 [39.5], p < 0.001), presence of atopy (52.4% vs 10%, p = 0.01), and presence of aspirin-exacerbated respiratory disease (AERD) (27.3% vs 0%, p = 0.022), with lower levels of IgE and lower percentages of atopy and AERD in biologic treatment-naïve patients (Table 3). The gene discussed is IGHE; the disease is respiratory system disorder.