THBS1 and cancer: The subgroup analysis of cancer type indicated that TSP-1 have a statistically significant association with the breast cancer group (HR = 1.80, 95%CI: 1.20–2.71; P = 0.004) and gynecologic cancer group (HR = 1.79, 95%CI: 1.18–2.71; P = 0.006) (Fig. 4C).