Zinc finger E-box-binding homeobox 1 (ZEB-1) and Zinc finger E-box-binding homeobox 2 (ZEB-2) are well-known drivers of epithelial-mesenchymal transition (EMT) [29], which not only promote normal embryonic development but also contribute to cancer progression and metastasis [30–32]. The gene discussed is ZEB2; the disease is cancer.