Bcl2 is an antiapoptotic protein; while its rearrangement is typically seen in FCL, some DLBCL and double/triple hit lymphomas, Bcl2 is also widely and differentially expressed in other B-NHL lacking t(11;14), including CLL and MZL [34,35,36,37]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.