As shown in Figure 4A, Dox-resistant variants and snoRNA-overexpressing Dox-sensitive cells shared the up-regulation of growth arrest and DNA-damage-inducible α (GADD45A), a sensor of stressing conditions that increases after DNA damage [35], and c-MYC, an oncogene commonly amplified or mutated in cancer that favors cell cycle progression [36]. Here, GADD45A is linked to cancer.