CSPG4 and malignant glioma: NG2/CSPG4 has a role in blood vessel development both in the normal brain [58] (where blood vessel development is altered in NG2/CSPG4 null tumors [44]) and in the proliferative vessels of malignant gliomas [42,59,60,61] (where ECs are preceded and even guided by migrating pericytes during the organization of the growing vessel wall [23,62]).