EPCAM and hepatocellular carcinoma: We identified that, among CTCs and DTCs from various entities, the unique population of EpCAM+ CTCs and DTCs with cytogenetic abnormalities of aneuploid chromosome 8 as the particular subtype accounting for the systemic metastasis in breast cancer patients [82] and the metastatic recurrence in postsurgical hepatocellular carcinoma patients [83].