IFNG and neoplasm: Tumor subtypes with lower host immune response and with increased levels of the TGF-β, with a high content of M2 macrophages and an immunosuppressed TME tend to have the worst outcomes [186], while the subtypes rich in IFN-γ and with an inflammatory profile were found to be much more frequent, to share a Th1-like immune response and show more favorable prognosis [186].