On the other hand, given the observations that endogenous Wnt signaling is unproportional to telomerase activity level, and that TERT overexpression hyperactivates the Wnt pathway in only one out of four breast cancer cell lines, the Blackburn lab proposed in 2014 that TERT participation in Wnt signaling is highly context-dependent [106]. This evidence concerns the gene TERT and breast carcinoma.