The same 10 CRC paired tissue samples were analysed for gene expression of GRIA4, VIPR2 and two additional genes, SPOCK1 and SLC6A3, whose CGIs were hypermethylated in our CRC discovery set and successfully validated in TCGA dataset (Figure 2 and Table 1) [4]. The gene discussed is VIPR2; the disease is colorectal carcinoma.