Their anti-tumor effect relies on their direct cytolytic activity against transformed cells and their ability to stimulate and regulate the biological functions of other cell types, such as dendritic cells (DC), interferon-γ-producing CD8 αβ T-cells, and natural killer (NK) cells, that are required for the initiation and the establishment of an efficient anti-tumor immune response [14,15,16,17]. This evidence concerns the gene CD8A and neoplasm.