PECAM1 and neoplasm: The study by Wu [50] had the greatest reduction in CD31 expression with Lut with folic acid modified poly(ethylene glycol)-poly(e-caprolactone) (Lut/Fa-PEG-PCL) application (89% compared to the control group), significantly inhibiting the neovasculature of the GL261 tumor and playing an important role in inhibiting tumor cellular growth.