The study by Bechet [63] showed an intense decrease of Ki67 and VEGF protein expressions in the tumor tissue immediately after interstitial photodynamic therapy (iPDT), and the study by Hekmatara [68] showed that DOX in solution led to a slight decrease in necrosis and microvascular proliferation, whereas DOX bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles drastically decreases necrosis and led to the complete disappearance of microvascular proliferation. Here, MKI67 is linked to neoplasm.