VEGFA and neoplasm: Results showed a decrease in proliferating cells and tumor vessel area after SFN-LNCs treatment [34], no blood flow existed in the tumor region following treatment with CARD-B6 [53], vessel dilation and hemorrhaging within the tumor exposed to VEGF-NSs and PEG-NSs [48], and restored basement membrane architecture (BMA) and reduced blood vessel diameter (BVD) of the tumor vasculature, suggesting restoration of the vessel architecture to a more normal state after Irinophore CTM treatment, occurring vascular normalization [43].