With less efficiency in the ability to reduce CD31 expression (19–21%), the study by Clavreul [34] showed that lipic nanocapsules with SFN (SFN-LNCs) decreased the proportion of proliferating cells and the tumor vessel area 7 days after the end of treatment, inducing an early increase in tumor blood flow and vascular normalization process. This evidence concerns the gene PECAM1 and neoplasm.