PECAM1 and neoplasm: The study by Verreault [43] performed double detection of CD31 and Collagen IV after Irinophore CTM administration and they quantified different structures involved in the angiogenic process: the extent of discontinuous basement membrane, the fraction of pericyte-uncovered blood vessels in tumor tissue, the blood vessel diameter, and the proportion of empty basement membrane sleeves that indicates the regression of pre-existing blood vessels suggesting a more homogenous distribution of blood across the entire tumor.