In addition, the plant-based medicines used in angiotherapy, mainly GBM therapy reported in the selected studies already are well described in the literature, regarding its antiangiogenic and antimetastatic action that occurs targeting different molecular pathways, for example, the inhibiting VEGF production and the expression of HIF-1by taxanes, inhibition of the action of Topoisomerase I by alkaloids, suppressing the production of plasminogen activator (PA) and PA inhibitor-1 by flavonoids, among other targets of angiogenesis pathways [110,111,112]. The gene discussed is VEGFA; the disease is glioblastoma.