In particular, we show here for the first time that KIT inhibition in GISTs induced the profound changes in GIST secretomes, reflecting a massive secretion of the multiple chemokines (e.g., MCP-3, GRO, IP-10, FGF-2, and VEGF) known to be elevated in many types of human cancers, and promoting cancer cell invasion and migration. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.