PDGFRB and neoplasm: Moreover, in addition to the direct proangiogenic effects of FGFR-signaling, the activation of this pathway might have a strong impact on neoangiogenesis via the activation of VEGFR-signaling and thereby may synergize with VEGFR and platelet-derived growth factor receptor (PDGFR)-mediated pathways to promote tumor vascularization [25,26].