FGFR2 and gastrointestinal stromal tumor: Interruption of the FGF-2/FGFR signaling via neutralizing anti-FGFR-2 Abs abolished this effect, thereby revealing that IM-induced activation of the FGF-2/FGFR autocrine loop is responsible for increased migration and invasion of IM-resistant GIST T-1R cells.