FGF2 and gastrointestinal stromal tumor: Given that IM-treated GIST T-1R cells actively produce FGF-2 (Figure 1C) and taking into account that the inhibition of FGFR-signaling restores their sensitivity to IM [15,16], we sought to examine whether the activation of FGFR-signaling might be a mechanism that rescues IM-naïve GIST T-1 cells from IM treatment.