To assess the impact of the inhibition of KIT signaling on GIST secretomes, we initially utilized the IM-sensitive GIST T-1 cell line, which exhibits a heterozygous 57-base pair deletion (V570-Y578) in KIT exon 11 [20], and the IM-resistant GIST T-1R subline generated in our laboratory, as shown elsewhere [15]. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.