Recent studies suggested that the three Parkinsonism-associated proteins parkin, phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (pink1), and DJ-1 (Parkinson disease protein 7, PARK7), that functionally associate with mitochondria work in parallel to protects cells from oxidative stress and confer neuroprotection in neuronal cells [38,39]. This evidence concerns the gene PINK1 and Parkinsonism.