For instance, SERCA2b expression is positively correlated with colorectal malignancy as SERCA2b over-expression promotes pro-survival mitogen-activated protein kinase (MAPK) and protein kinase B (also known as AKT) signaling and drives proliferation and migration of human colorectal adenocarcinoma SW480 cells [179]. This evidence concerns the gene AKT1 and colorectal adenocarcinoma.