ATP2A3 and breast carcinoma: Since cancer is a multifactorial disease, it is not surprising that even a combination of SERCA2(b) up-regulation and SERCA3 isoform down-regulation exists in the case of epidermal growth factor-induced epithelial mesenchymal transition in breast cancer MDA-MB-468 cells, further solidifying the link between aberrant SERCA activity and malignancy [184].