PTEN and Familial prostate cancer: For instance, tumor suppressor proteins phosphatase and tensin homolog (PTEN) in human prostate cancer and BRCA1-associated protein-1 (BAP1) in asbestos-induced malignant transformation partially act through stabilizing IP3R3s against receptor ubiquitination; thus, potentiating Ca2+ transport into the mitochondria to drive apoptosis [114,115].