As the role of Orai3 in facilitating tumorigenicity became more prominent, Dubois et al. discovered increased endogenous expression of Orai3 protein and increased reliance on the use of Orai3-Orai1-jointly-mediated store-independent, arachidonic-acid-regulated channels among prostate cancer cells. The gene discussed is ORAI1; the disease is Familial prostate cancer.