Moreover, recent study shows that, diffuse large B-cell lymphoma (DLBCL) cells with constitutive IP3 signaling and addiction to Bcl-2-mediated attenuation of IP3R2 Ca2+ release are sensitive to apoptotic induction by Bcl-2/IP3R Disruptor-2 (BIRD2), which is compatible with the previous finding in DLBCL that increased IP3R2 protein level is associated with high sensitivity to apoptosis among SU-DHL-4 cells subsequent to treatment with BIRD2 [130,131]. Here, BCL2 is linked to diffuse large B-cell lymphoma.