BCR and neoplasm: PFS, or median time from pathologic diagnosis to a new tumor event, defined as BCR, LRR, DM, or death was 29.5 months in cluster 1, 30.1 months in cluster 2, 23.1 months in cluster 3, and 26.1 months in cluster 4 (global p-value < 0.0001, Figure 2).