TP53 and malignant peripheral nerve sheath tumor: Numerous subsequent studies have focused on identifying the true incidence of TP53 mutation in human MPNST; from compiled data on 25 studies including 114 MPNST (both NF1-associated and sporadic), TP53 mutations were observed in 14% of MPNST, with LOH in 39% of cases (Table 1) [39].