In addition to loss of NF1 and PRC2function, BRAF mutations are reported as an alternate mechanism for aberrant activation of RAS signaling in MPNST, albeit at a lower frequency (ranging from 0–9.7%) [32,47,69,78,79], and occurring more commonly in sporadic than NF1-associated cases [78]. The gene discussed is BRAF; the disease is malignant peripheral nerve sheath tumor.