Somatic LOH analysis using PCR markers performed on the NF1 locus in dermal neurofibromas identified deletions in a subset of tumors in several early studies [53,54]; those cases known to be familial were analyzed further and shown to have deletions in the non-germline allele, demonstrating that somatic inactivation of NF1 occurs in these benign lesions. Here, NF1 is linked to dermal neurofibroma.