SERPINB3 inhibited cysteine proteases, and SERPINB4 influenced chymotrypsin enzymes, functions that may extend opportunistic bacteria.53 SERPINB3 was upregulated in barrier compromise, for example, atopic dermatitis, psoriasis, and irritant exposure,54 suggesting provision of immunity.53 This evidence concerns the gene SERPINB3 and atopic eczema.