In the Lehmann-Kalata study [18], the authors found a statistically significant difference in TNF-a R1 (TNF-a receptor 1) salivary concentration between obese patients and people without obesity (higher in obese subjects), which could indicate an increase in TNF-a concentrations in people with obesity. The gene discussed is TNFRSF1A; the disease is obesity due to melanocortin 4 receptor deficiency.