Among the common gene mutations in AML, patients with DNMT3A overexpression showed lower NPM1 and DNMT3A mutation rates (P=0.000 and 0.002, respectively), whereas cases with DNMT3B underexpression presented lower frequency of IDH1 and TP53 mutation (P=0.038 and 0.005, respectively). The gene discussed is TP53; the disease is acute myeloid leukemia.