CARD14 and psoriasis: Genetic background also contributes to the penetrance of gain-of-function CARD14 mutations in promoting psoriasis (Bhalerao and Bowcock, 1998), as recently confirmed in mouse studies in which the survival of mice with a constitutive Card14E138A mutation is increased by crossing C57BL/6 mice onto a 129S4 background (Sundberg et al., 2019).