Importantly, several genes relevant to the pathology of psoriasis (S100a9, Il1f9, Cxcl2, Il17a and Tnfa) remained significantly elevated in Card14LSL-E138A/+Rosa26CreERT2/+ mice at 1 m and may be necessary in maintaining the inflammatory skin phenotype promoted by chronic CARD14E138A signalling. The gene discussed is IL17A; the disease is psoriasis.