The increased expression of Steap1 and Steap4 mRNAs in the skin of Card14LSL-E138A/+Rosa26CreERT2 mice after tamoxifen injection is particularly interesting since these genes have been found to be upregulated in several types of pustular psoriasis and are known to be important in neutrophil chemotaxis (Liang et al., 2017b). The gene discussed is STEAP1; the disease is pustular psoriasis.