Tamoxifen induced a skin phenotype very similar to Card14LSL-E138A/+Rosa26CreERT2/+Rag1+/+ controls, with acanthosis, hyperkeratosis, S100A9+ myeloid cell infiltration and expression of chemokines and proinflammatory cytokines at 5d following tamoxifen injection (Figure 2E,F,G,H and Figure 2—figure supplement 1F,G,H and I). Here, RAG1 is linked to Hyperkeratosis.