Consistent with this, the highly penetrant CARD14E138A psoriasis-associated mutation, first identified as a sporadic mutation in a child suffering from GPP (Jordan et al., 2012b), induces CARD14 interaction with BCL10 (B cell lymphoma protein 10) and the paracaspase MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) (Howes et al., 2016). The gene discussed is CARD14; the disease is psoriasis.