CYP7A1 and metabolic syndrome: Dyslipidemia with hepatic cholesterol accumulation has previously been suggested to be associated with Cyp7a1 repression found in cholestasis, as downregulation of bile acid synthesis from cholesterol leads to cholesterol accumulation in the liver (36, 48), suggesting that cholesterol accumulation in the liver may be proportional to hepatic Cyp7a1 repression in our model.