Previous studies demonstrated the association of mutations in SMAD3 and the form of aneurysms and dissections (Hilhorst‐Hofstee et al., 2013; Van De Laar et al., 2011e Laar et al., 2011; Regalado et al., 2011) therefore, the two families were informed of the possible risk for aortic disease and a family study was initiated. The gene discussed is SMAD3; the disease is aneurysm.