Mutations in SMAD3 may lead to deficiency and disruption of TGF‐β signaling pathway which were reportedly appeared to cause histological disorganization of the media layer, elastic fiber fragmentation and loss as well as collagen accumulation in the media layer which are associated with the development of aortic aneurysms (Berthet, Hanna, Giraud, & Soubrier, 2015; Chacko et al., 2004; Van De Laar et al., 2011e Laar et al., 2011; Regalado et al., 2011). This evidence concerns the gene TGFB1 and aortic aneurysm.