Less than 10% of patients suffer from monogenic PD, which is predetermined by modifications of risk genes, Parkin, DJ‐1, PINK1 ATP13A2, DNAJC6, PLA2G6, FBOX7 and SYNJ1, SNCA, LRRK2, VPS35, etc.14, 15, 16, 17, 18, 19, 20However, most patients suffer from idiopathic, or sporadic PD, a multifactorial disease caused by a combination of genetic and epigenetic factors (age, environment, lifestyle, brain injury, etc.).8, 17, 21, 22, 23, 24. This evidence concerns the gene PRKN and Parkinson disease.