When Hodgkin and RS cells and granulomatous reactions are seen in ATLL and PTCL tissues, it is necessary to check for nuclear atypia in background lymphoid cells, populations of CD4+/CD8+ T cells, follicular helper T‐cell markers, and rearranged TCR Cβ1 genes to differentiate HL.10, 11. This evidence concerns the gene CD4 and adult T-cell leukemia/lymphoma.