MTOR and Nephropathy: pS6RP expression, a downstream target of mTOR, increases in PECs in FSGS and healthy aging in mice (McNicholas et al., 2016), in experimental injury models including adriamycin nephropathy, puromycin aminonucleoside nephropathy, and crescentic glomerulonephritis in the rat (Hamatani et al., 2014; Kurayama et al., 2011).