The current thinking around glomerulosclerosis, a hallmark of kidney aging, is evolving from the original podocyte‐centric view, to one that also includes the activated glomerular parietal epithelial cell (PEC), often defined as de novo expression of CD44 (Fatima et al., 2012; Smeets et al., 2009), and increased pERK (Eng et al., 2015; Roeder et al., 2017). Here, CD44 is linked to glomerulosclerosis.