At 4 weeks post‐MI, Masson's trichrome staining showed no significant improvements in infarct size in VEGF‐treated mice compared with PBS‐treated mice (Figure 1A), but distinct reductions in IGFBP‐4–treated and dual VEGF/IGFBP‐4–treated mice (Figure 1B), indicative of decreased degree of cardiac fibrosis. This evidence concerns the gene IGFBP4 and fibrosis.