At the same time, G6PD prolongs the half‐life of HIF‐α by inhibiting its ubiquitination and causes HIF‐α to be highly expressed in tumour cells and then decreased the intracellular ROS content immediately, which may be the underlying reason why piRNA‐823 high expression leads to the escape of colorectal cancer cells from death. The gene discussed is G6PD; the disease is colorectal cancer.