Importantly, knockdown of c‐Jun by two independent siRNAs, whose efficiency was confirmed in Figure 6C by Western blotting, could reverse MUC12‐mediated induction of TGF‐β1 levels (Figure 6D) as well as MUC12‐mediated increase of RCC cell invasion (Figure 6E). This evidence concerns the gene JUN and renal cell carcinoma.