In CRC, several RNA processing factors, including HNRNPLL, SRSF1, SRSF3 and SRSF6, have been shown to actively participate in tumour progression and have demonstrated prognostic value, indicating that genetic alterations affecting RNA splicing are associated with CRC pathogenesis.10, 11, 12, 13. The gene discussed is SRSF3; the disease is colorectal carcinoma.