More specifically, the Ras/MAPK pathway was regulated by alternative splicing with regard to variants of EGFR, BRAF, p19‐ or p21‐Ras, MEK1b and ERK1c44; activation of the MAPK pathway also required serine/arginine‐rich splicing factor 1 (SRSF1), a splicing factor that can promote tumorigenesis in CRC.45, 46. This evidence concerns the gene SRSF1 and colorectal carcinoma.