We found that genes involved in the RAS oncogene family (eg RAB15 and RAB23), various splicing factors (eg DUSP11, HNRNPLL, HNRNPC), aberrant RNA splicing in CRC (eg CD44) and receptor tyrosine kinase signalling (eg FGFR1) were differentially spliced among CRCs with lower and higher RPGIs (Figure 4B). Here, RAB15 is linked to colorectal carcinoma.