However, the induction of SOX2 could not completely restore cancer stem cell properties attenuated by the suppression of COX2 and YAP1, raising the possibility that YAP1 and COX2/PGE2 signalling as well as other tumorigenic pathways may also contribute to the maintenance of SOX2‐independent CSCs along with an aggressive tumour behaviour.12, 46. This evidence concerns the gene SOX2 and neoplasm.