SOX2 and cancer: However, the induction of SOX2 could not completely restore cancer stem cell properties attenuated by the suppression of COX2 and YAP1, raising the possibility that YAP1 and COX2/PGE2 signalling as well as other tumorigenic pathways may also contribute to the maintenance of SOX2‐independent CSCs along with an aggressive tumour behaviour.12, 46