As shown in Figure 1(a), YTHDF1 (P < 0.001), METTL3 (P < 0.001), and KIAA1429 (P < 0.001) were significantly upregulated, while YTHDF3 (P < 0.001), YTHDC2 (P = 0.020), METTL14 (P < 0.001), and ALKBH5 (P < 0.001) were significantly downregulated in COAD samples compared to normal samples. This evidence concerns the gene METTL3 and colon adenocarcinoma.