CCR2 and neoplasm: The tumor-associated macrophages (TAMs) may either be monocyte derived or microglia origin; a study using florescence reporter mice under control of CX3CR1 and CCR2 promoters showed that CX3CR1lowCCR2hi monocytes were recruited to the glioblastoma and transitioned into CX3CR1hiCCR2low macrophages and CX3CR1hiCCR2− microglia-like cells [70].