The levels of NT-proBNP, hs-CRP, and MMP-28 were significantly higher in patients with acute ST-elevation myocardial infarction (STEMI) than in patients with non-ST-elevation myocardial infarction (NSTEMI) (P < 0.01). The gene discussed is NPPB; the disease is ST Elevation Myocardial Infarction.