30 cell cycle genes had a potential prediction value, with all P values < 0.05 and AUC > 0.8 for the GEO and TCGA datasets (Supplementary Table 5); CDC14B, CDC20, CDK1, MCM2, MCM6, and MCM7 in particular exhibited high accuracy in differentiating HCC tissues from nontumor tissues (Figure 2, P values < 0.05, AUC > 0.8 for all cases). Here, CDC20 is linked to hepatocellular carcinoma.