Kaplan-Meier analysis suggested that the high expression of 9 genes, CDKN1C, CDC25B, CDC20, PTTG2, SMC3, RAD21, EP300, CDC25A, and MCM5 and low expression of 3 genes, MAD1L1, GADD45A, and GADD45G were associated with RFS in HCC (P values < 0.05 for all cases, log-rank test, supplementary table 7). This evidence concerns the gene MCM5 and hepatocellular carcinoma.