Rogaratinib (BAY1163877) is a selective oral inhibitor of FGFR1-4; promising results have been reported from a phase I expansion cohort in advanced bladder cancer patients prescreened for FGFR1 or 3 mRNA expression levels by RNA-ISH (NCT01976741) [13]. The gene discussed is FGFR1; the disease is urinary bladder carcinoma.