TTR and neoplasm: The optimal cut-off level based on 5-year OS was determined to be 527 for the SII, 48.73 for the PNI, 2.2 for the NLR, 6.17 for leukocyte count, 3.27 for neutrophil count, 3.06 for fibrinogen level, 121.2 for hemoglobin level, 234.5 for prealbumin level, 42.5 for albumin level, 29.9 for globulin level, and 4.75 for tumor size (Table 2).