There was a significant difference between the low SII (<527) group and the high SII (≥527) group in terms of tumor size (p < 0.001), infiltration of serosa (p < 0.001), lymph node metastasis (p < 0.001), TNM stage (p < 0.001), leukocyte count (p < 0.001), neutrophil count (p < 0.001), serum hemoglobin level (p < 0.001), plasm fibrinogen level (p < 0.001), serum prealbumin level (p = 0.005), the PNI (p < 0.001), and the NLR (p < 0.001). This evidence concerns the gene TTR and metastatic malignant neoplasm in the lymph nodes.