As shown in Figure 1, the upregulated DEGs were enriched in KEGG pathway of cell cycle, DNA replication, and P53 signaling pathway, and downregulated DEGs were mainly associated with Complement and coagulation cascades, Staphylococcus aureus infection, Rheumatoid arthritis, and cell adhesion molecules (Figure 1(d)). This evidence concerns the gene TP53 and rheumatoid arthritis.