Animal studies have shown promising results; in rabbit scleral fibroblasts, MMP-2 expression is reduced and TIMP-2 expression is increased after posterior sclera reinforcement [30]; in Guinea pigs, oral intake of anthocyanin compounds reduce scleral MMP-2 expression and collagen I degradation in a form-deprivation model [29]; in Guinea pig models of lens-induced myopia, riboflavin combined with ultraviolet A irradiation results in a lower net increase in MMP-2 and a lower net decrease in TIMP-2, compared to the control group [31]. The gene discussed is MMP2; the disease is myopia.