When Hp was measured in saliva, it was significantly higher in bitches with canine pyometra [median (25th−75th percentile) [3.09 (1.39–10.24) μg/mL] in comparison to healthy ones [0.24 (0.19–0.61) μg/mL] (p < 0.001). The gene discussed is HP; the disease is pyometritis.