Interestingly, in an in vivo model ApoE−/−, Nlrp3−/−, ApoE−/−, Asc−/−, ApoE−/−, and caspase-1−/− double-deficient mice fed a high-fat diet failed to demonstrate differences in atherosclerosis progression and phenotype of the plaque (90). This evidence concerns the gene NLRP3 and atherosclerosis.