Together with our previous findings, these results suggested that MK2 was required for fMLF-induced activation of Akt, p38 MAPK, and NADPH oxidase in neutrophils, and MK2 ablation in the myeloid lineage cells had a negative impact on the activation of Akt, p38 MAPK, and NADPH oxidase, resulting in the reduction of ROS production by neutrophils, therefore alleviating IBD. Here, FMO5 is linked to inflammatory bowel disease.