MAPKAPK2 and inflammatory bowel disease: Thus, compared to wild-type mice that had higher levels of inflammatory cytokines and ROS in injured intestinal tissues, MK2 knockout in myeloid significantly reduced the levels of inflammatory cytokines and ROS at the early phase of IBD in MK2lyz2−KO mice and moderate inflammation not only alleviate tissue injury but also contribute to epithelial proliferation and regeneration.