SRSF1 and Familial prostate cancer: The overexpression of SRSF1 was also shown to increase cell proliferation through the production of the exon 5 lacking-variant cyclin D1b in prostate cancer and to induce epithelial mesenchymal transition by stimulating the production of the ΔRon variant in breast cancer (Ghigna et al., 2005; Olshavsky et al., 2010).