TP53 and cancer: Characterization of known transcripts from RNA-seq data of 4,542 tumor samples from 11 cancer types recorded in TCGA revealed the presence of 8,122 switches in the RNA isoforms encoded by 6,442 genes, the most common being RAC1 gaining an extra Ras domain and TP53 losing coding capacity (Climente-Gonzalez et al., 2017).