Moreover, the hnRNP D reduces the Dicer1 levels by targeting the 3′-UTR of DICER1 mRNA, causing down-regulation of tumor suppressor miR-122 and increased viability of PLC/PRF/5 hepatoma as well as Huh7 liver derived cell lines (Wu et al., 2018). This evidence concerns the gene DICER1 and hepatocellular carcinoma.