The hnRNP D, that is overexpression in Eca-109 esophageal cancer cell line, has been recognized to bind the 3′-UTR AU-rich motifs of GTP cyclohydrolase (GCH1) transcripts causing GCH1 overexpression and enhanced cell proliferation and colony formation (Gao et al., 2016). The gene discussed is GCH1; the disease is esophageal cancer.