In particular, the overexpression of BRM gene enhances the inclusion of exon 9 in the E-caderin mRNA in the MCF-7 human breast cancer cell line, while the Brm knockdown promotes the production of a cyclin D1b variant lacking exon 27 in Caco2 cell lines (Batsche et al., 2006). The gene discussed is SMARCA2; the disease is breast cancer.