Either SRPK1 siRNA knockdown or treatment by SPHINX and SRPIN340 inhibitors reduced the SRSF1, SRSF2 and SRSF5 phosphorylation causing increased production of the anti-apoptotic VEGF165b isoform in PC-3 prostate cancer cell line (Mavrou et al., 2015). The gene discussed is SRSF1; the disease is prostate cancer.