MKNK2 and neoplasm: Furthermore, 2′-O-methylated SSO, targeting the 3′-splice site in exon 14b of MKNK2 mRNA, enhances the tumor-suppressor Mnkn2a isoform levels, leading to increased phosphorylation and activation of p38α–MAPK and overexpression of cFOS, COX2 and IL-6 target genes (Mogilevsky et al., 2018).