Moreover, hotspot mutations in the SRSF2 gene, such as P95H, change the binding properties of the SRSF2 protein and cause genome-wide splicing network alteration and aberrant maturation of different hnRNPs, including HNRNPA2B1, HNRNPM, HNRNPH1, and HNRNPH3, especially in myelodysplastic syndromes (Komeno et al., 2015; Arbab et al., 2018; Aujla et al., 2018; Liang et al., 2018; Masaki et al., 2019). This evidence concerns the gene SRSF2 and myelodysplastic syndrome.