BIN1 and neoplasm: In particular, Karni et al. (2007) showed that SRSF1 regulates the alternative splicing of the tumor suppressor BIN1 and kinases MNK2 and S6K1 causing the production of a BIN1 isoform lacking tumor-suppressor activity, a MNK2 isoform promoting MAP kinase-independent eIF4E phosphorylation, and an oncogenic S6K1 isoform in transformed NIH 3T3 and Rat1 cell lines.