Hypocalcemia, and to some degree calciferol deficiency, results in increased section of PTH from the parathyroid glands (i.e., secondary hyperparathyroidism), which leads to decreased reabsorption of phosphate and bicarbonate in the proximal renal tubule, resulting in hypophosphatemia and hyperchloremic acidosis, respectively. This evidence concerns the gene PTH and hypophosphatemia.