Conversely, Rottembourg et al. found low inhibin B (31–114 pg/mL) concentrations in four boys with PSIS and spontaneous puberty, one of whom had a history of micropenis and cryptorchidism; the authors suggested that the boys had gonadotropin dysfunction that was not detectable by conventional GnRH testing (20). Here, GNRH1 is linked to pituitary stalk interruption syndrome.