Besides, the airway remodeling depicted by patients with exacerbated lung fibrosis, has been associated with elevated plasma levels of AngII (angiotensin II), which could trigger TGF-β1 production and collagen deposition (Uhal et al., 2007; Gao et al., 2009; Yang et al., 2009). Here, TGFB1 is linked to pulmonary fibrosis.