For example, LPS activated macrophages will undergo glycolysis metabolism changes, while IL-4 activated macrophages will produce oxygen and phosphorus, both of which indicate that metabolic adaptation during macrophage activation is a key component of macrophage polarization, which helps them play a role in infection and tumor inflammation, but their precise roles in regulating the differentiation of macrophages and in regulating infection and tumorigenic inflammation remain unclear. Here, IL4 is linked to neoplasm.