Similar to normal iDCs, upon infection with herpes simplex virus type 1 (HSV-1) LADIII iDCs downregulated CD83 (Figure S3), a reaction that is proteasome-dependent and not known to require integrin signaling (Salio et al., 1999; Kruse et al., 2000; Kummer et al., 2007). This evidence concerns the gene CD83 and infection.