Core 2 O-glycans is catalyzed by β-1,6-N-acetylglucosaminyltransferase (core 2 β-1,6 GlcNAc transferase or C2GnT), and found that C2GnT expression is positively correlated with urinary system tumors such as bladder cancer (38, 39). The gene discussed is GCNT1; the disease is urinary bladder cancer.