For example, in tumor cells, overexpression of OGT adds O-GlcNac to Thr-352 of NF-κB p65, this process can decreases binding to IκBα, so that NF-κB can play its role of transcription factors through entering the nucleus, which leads to cell division defects and cloning (50). This evidence concerns the gene NFKB1 and neoplasm.